The issue of blisters that shadowed Shohei Ohtani during his first five pro seasons in Japan has come with him to the major leagues.

The Los Angeles Angels' slugging right-handed pitcher left Tuesday's 10-1 loss to the Boston Red Sox after 66 pitches over two innings due to a blister he said first surfaced during his last start, nine days earlier.

"After my previous start, it was just there a little, but I felt I could still make a go of it," Ohtani (2-1) said after suffering his first loss since coming to the majors this season.