Shingo Kawabata and Kazuhiro Hatakeyama each hit two-run, first-inning home runs on Friday as the Tokyo Yakult Swallows beat the Seibu Lions 8-4 to end their winless start to interleague play.
The Lions, who are last in the Pacific League, have lost all three of their games thus far against Central League opposition this season.
Seibu starter Ryoma Nogami dug himself a hole in the first before a crowd of 14,690 at Seibu Dome.