High-profile Republicans and rank-and-file voters on Wednesday struggled with how to best reject Donald Trump's divisive candidacy, as the nominee dealt with fallout from his remark that gun rights activists could stop Hillary Clinton from nominating liberal U.S. Supreme Court justices.

MSNBC host Joe Scarborough, a former Republican congressman from Florida, wrote an opinion piece in the Washington Post saying the party was in "uncharted waters" and called for leaders to start looking for ways to remove Trump from the ticket.

A new Reuters/Ipsos poll taken Aug. 5-8 showed that nearly one-fifth of 396 registered Republicans want Trump to drop out of the race for the White House and another 10 percent "don't know" whether the Republican nominee should or not.