Yu Darvish allowed two runs on seven hits and was charged with the loss as the San Diego Padres went down 4-0 to the Los Angeles Dodgers on Sunday.
Darvish (10-5) surrendered a solo homer to Cody Bellinger and an RBI single to Freddie Freeman in the bottom of the third at Dodger Stadium.
The right-hander struck out five and did not issue a walk in his six-inning start, but he got little support from a Padres lineup that managed just two hits against Tyler Anderson (13-1) over seven innings.
Completing a three-game series sweep, the National League West-leading Dodgers delivered a statement against their divisional rivals, who had signaled their playoff intentions by acquiring superstar Juan Soto and former All-Star Josh Bell at the trade deadline.
At Citi Field, New York Mets right-hander Jacob deGrom (1-0) broke Darvish's MLB record for most strikeouts through 200 career appearances, notching No. 1,523 in a 5-2 win over the Atlanta Braves in his return to the mound after a year-plus absence.
Shohei Ohtani registered his 100th hit of the season in a 1-for-4 outing at T-Mobile Park, singling in the fifth inning of the Los Angeles Angels' 6-3 loss to the Seattle Mariners.