April 1979 to June 1989: Masuzoe is an assistant professor at the University of Tokyo, his alma mater.
April 1999: He loses to Shintaro Ishihara in a Tokyo gubernatorial election.
July 2001: Masuzoe elected to the Upper House on a Liberal Democratic Party ticket.
Aug. 2007 to Sept. 2009: He serves as health, labor and welfare minister in three administrations, including during Shinzo Abe's first stint as prime minister.
April 2010: Masuzoe quits LDP to head the New Renaissance Party.
December 2012: Tokyo Vice Gov. Naoki Inose wins Tokyo gubernatorial election.
June 2013: Masuzoe chooses not to run in the July Upper House election, acknowledging failure to increase his party's standing.
September 2013: Tokyo wins bid to host 2020 Olympics.
December 2013: Inose resigns in a scandal involving ¥50 million received from hospital chain operator Tokushukai.
February 2014: Masuzoe wins a landslide victory in the Tokyo gubernatorial race, with support of LDP and Komeito. Defeated rivals include former Prime Minister Morihiro Hosokawa.
April 2016: Weekly magazine Shukan Bunshun reports that Masuzoe routinely used official vehicles to travel to his vacation home.
May 2016: Masuzoe admits to booking private hotel and dining bills as political expenses. He apologizes.
June 6, 2016: Investigators hired by Masuzoe say his use of ¥4.4 million was improper but not illegal.
June 15, 2016: Masuzoe quits.