Researchers from Yamanashi University's faculty of medicine have found that severe allergic symptoms at night and in the morning may be caused by high activation of genes in the mast cells during those hours.
The research group led by Atsuhito Nakao, a professor in the department of immunology at Yamanashi University, said if the activation of genes can be controlled by medicine, it would help control when patients come down with asthma and hay fever symptoms.
According to their study, the genes, called "clock genes," drive the daily rhythm by inducing vibration inside the mast cells.