Director Hidetaka Inazuka, known for his documentary on the double atomic-bomb survivor, has completed a new film on three Japanese children fighting a very rare and little-known disease that has left them mostly immobile since birth.

The film, titled "Kiseki no Kodomotachi" ("Miracle Children"), features three children, two of whom are brother and sister, who suffer from aromatic L-amino acid decarboxylase deficiency — a genetically inherited neurological disorder caused by a lack of an enzyme related to physical mobility.

It documents about 10 years of the children's life, from when they were very young, bed-ridden and unable to speak, to more recent times in which they have shown dramatic improvement as gene-repair therapy has allowed them some mobility with the help of a walker.