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After decades of work, the World Health Organization endorsed the first-ever malaria vaccine last year — a historic milestone that promised to drive back a disease that kills a child every minute.

In reality, efforts are falling well short of that, with a lack of funding and commercial potential thwarting GSK PLC’s capacity to produce as many doses of its shot as needed, according to interviews with about a dozen WHO officials, GSK staff, scientists and nonprofit groups.

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