U.S. Sen. Joe Manchin, a moderate Democrat who is key to President Joe Biden's hopes of passing a $1.75 trillion domestic investment bill, said on Sunday he would not support the package, drawing a sharp rebuke from the White House.

Manchin appeared to deal a fatal blow to Biden's signature domestic policy bill, known as Build Back Better, which aims to expand the social safety net and tackle climate change.

"I cannot vote to continue with this piece of legislation," Manchin said in an interview with the "Fox News Sunday" program, citing concerns about inflation. "I just can't. I have tried everything humanly possible."