News of the blowup spread through financial circles in Tokyo to the pulse of a familiar refrain: "Not again."

Nomura Holdings Inc. had run into trouble far from home, this time, with the giant implosion of Archegos Capital Management in New York. Few institutions have been as humbled by the Archegos debacle as Nomura, the forever-striving giant of Japanese finance.

The question now is how, or perhaps whether, Nomura can shake off this latest blow and press on with its global ambitions. Analysts wonder if heads will roll over the Archegos losses or if Nomura will quit certain businesses.