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The latest Republican attempt to repeal and replace Obamacare appeared headed for defeat after Sen. Susan Collins said she doesn’t see herself backing the current plan and Texas Sen. Ted Cruz said he’s currently “not a yes.”

Senate Majority Leader Mitch McConnell can afford to lose no more than two votes on the Graham-Cassidy health care bill. Two Republicans have so far said they oppose the measure — although the White House continues to hold out hope that one, Sen. Rand Paul of Kentucky, can be persuaded to change his position.

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