BEIJING – Chinese scientists apparently are embarking on the first human trials with the CRISPR gene-editing tool, the latest effort by the country’s researchers to master a technology that might someday be a potent tool in developing therapies worldwide.
The group, led by Lu You, an oncologist at the southwestern Sichuan University West China Hospital, has recruited the first patient for a 10-person clinical trial that will activate immune cells using CRISPR and infuse them back into patients to fight lung cancer. Due to potential risks in using the treatment for humans, the team has decided to treat the first group of three patients one at a time.
Formally called CRISPR-Cas9, the tool acts like a pair of precise molecular scissors that can cut out unwanted sections of DNA and insert desired ones. The team is using it to remove a gene that encodes a protein named PD-1, which normally keeps immune cells in check but is also used by cancer cells to hide from the immune system.
The engineering is intended to switch on the immune response to attack cancer. In the pharmaceutical industry, antibody drugs directly blocking the PD-1 protein, including Merck’s Keytruda and Bristol-Myers Squibb’s Opdivo, have become growth engines for the companies.
“If this technology has good safety and shows certain efficacy, it has wide applications,” said Lu. If successful, it has the potential to become an alternative biotechnology treatment to replace or complement the existing single-antibody drugs, Lu said.
Lu’s group received approval from the ethics board of the West China Hospital, one of the top facilities in the country.
They will observe the first patient for two months after injecting the CRISPR-edited cells. If there is no problem, they will give the second patient the same treatment. If the first three patients respond well, they may be able to accelerate after that.
“We’ve learned from past lessons that safety comes first. You have to make clear its safety profile before its preliminary efficacy can be discussed,” said Lu.
Patients must have the PD-L1 bio-marker and should have tried three to four lines of existing treatments and failed to benefit from them, he said.
Lu acknowledges it is still very early days. The Phase I trial only tests if the technology is safe, and Lu said his biggest worry is about overly activated immune cells attacking not just the cancer but also healthy cells, creating conditions similar to autoimmune diseases like lupus. Another problem is the possibility of unwanted mutations happening at sites other than the intended gene.
Chinese scientists were among the first in using CRISPR to make wheat resistant to a common fungal disease, dogs more muscular and pigs leaner.
In the southern city of Guangzhou, researchers sparked an international ethics debate last year after tweaking the genetic make-up of human embryos using CRISPR for the first time.
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