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IPS

By pioneering stem cell therapies, Japan is not only treating disease but also seeking to rejuvenate a nation grappling with aging and decline.
COMMENTARY / Japan
Jun 20, 2025
Japan is helping lead the way in regenerative medicine
In pristine labs across Japan, scientists are tinkering with the architecture of regeneration.
A Japanese team has started a final-stage clinical trial to administer to patients with familial Alzheimer's disease a drug discovered using iPS cells.
JAPAN / Science & Health
Jun 4, 2025
Japanese team starts final-stage trial for iPS drug to treat Alzheimer's
Through the trial, which began in May, the team aims to confirm the safety and efficacy of the treatment, with hopes of obtaining regulatory approval.
Kyoto University's Center for iPS Cell Research and Application in Kyoto
JAPAN / Science & Health
Apr 23, 2025
Japan team treats chronic kidney disease with iPS cells in mice
The hope is such an achievement leads to the development of an effective therapy for chronic kidney disease.
A 3D rendering of multiple induced pluripotent stem cells
JAPAN
Apr 18, 2025
University of Osaka team develops miniature livers from iPS cells
The team expects the small livers can be used to treat patients with end-stage liver disease.
Parkinson's disease is a neurodegenerative condition in which motor function is impaired due to a decrease in nerve cells that produce dopamine, a chemical that works in the brain.
JAPAN / Science & Health
Apr 17, 2025
Japan succeeds in improving Parkinson's symptoms with iPS cells
A trial saw nerve cells made from iPS cells transplanted into patients' brains.
It is the first transplant surgery in the hospital's clinical trial for treating Type 1 diabetes through the transplantation of pancreatic cell sheets made from iPS cells.
JAPAN
Apr 15, 2025
Kyoto hospital succeeds in iPS sheet transplant to diabetic patient
It is the first clinical application of such sheets in Japan.
A myocardial cell sheet using induced pluripotent stem (iPS) cells
JAPAN / Science & Health
Apr 9, 2025
Japanese startup seeks approval for world’s first iPS regenerative treatment
The Osaka University startup is targeting patients suffering from severe heart failure for whom current treatment options are limited.
Keio University in Tokyo
JAPAN / Science & Health
Mar 22, 2025
Keio University team says stem cell treatment helped improve spine injuries
Keio University said that the motor function score for two patients improved after an operation to implant more than 2 million iPS-derived cells into a spinal cord.
Researchers from Anicom Specialty Medical Institute, the National Institute of Genetics and Kazusa DNA Research Institute decoded the genome of American Shorthair cats and published the results in an article last October.
JAPAN / Science & Health
Mar 18, 2025
Japanese researchers set Guinness record for cat genome
Researchers decoded the genome of American shorthair cats and published the results.
Kyoto University's CiRA Foundation will automatically make autologous induced pluripotent stem cells and turn them into heart muscle and nerve cells at a new facility in the city of Osaka starting in April.
JAPAN / Science & Health
Jan 8, 2025
Automated iPS cell production to start in Japan in April
Autologous iPS cells will be created and turned into, among others, heart muscle and nerve cells.
A colony of human induced pluripotent stem (iPS) cells established from fibroblasts. Kyoto University Hospital is looking to develop a treatment for Type 1 diabetes using iPS cells.
JAPAN / Science & Health
Sep 3, 2024
Kyoto University Hospital seeks to treat Type 1 diabetes using iPS cells
Researchers will begin clinical trial of a treatment as early as next year, which they hope will become available in the 2030s.
Kyoto University's Center for iPS Cell Research
JAPAN / Science & Health
Jun 7, 2024
Japan team makes immune-controlling cells from human iPS cells
The team expects that the method can make it possible to mass produce the cells, known for their effectiveness in suppressing rejection in transplantation medicine.
Kyoto University researchers have found a way to create “near-indefinite” volumes of early-stage sperm and egg cells from iPS cells — a milestone that could potentially lead to new infertility treatments.
JAPAN / Science & Health
May 21, 2024
New Japan study on germ cells may help advance infertility treatments
The research aims to expand our understanding of how human germ cells develop, and also opens up possibilities for creating sperm and egg cells in a lab.
JAPAN / Science & Health
Jan 28, 2020
Osaka University transplants iPS cell-based heart cells in world's first clinical trial
An Osaka University team said it has carried out the world's first transplant of cardiac muscle cells created from iPS cells in a physician-initiated clinical trial.
JAPAN / Science & Health
Jan 25, 2020
Kyoto University team gets OK from ministry for plan to transplant iPS-derived cartilage into knee joints
An expert panel of the health ministry on Friday approved a clinical research program proposed by a Kyoto University team to transplant cartilage made from induced pluripotent stem (iPS) cells to damaged knee joints.
JAPAN / Science & Health
Jan 13, 2020
Gene abnormalities occur in iPS cell conversion process
Cancer-related genetic abnormalities have reportedly occurred during the process of transforming induced pluripotent stem (iPS) cells supplied by Kyoto University into intended cell types at recipient research institutes.
JAPAN / Science & Health
Dec 24, 2019
Japan approves research program to grow human organs in pigs
A science ministry committee on Monday approved a research program to grow human organs, such as the pancreas, inside the bodies of pigs for use in medical transplantation.
JAPAN / Science & Health
Sep 26, 2019
Japanese-led team creates functioning structure of mini-organs from human iPS cells
A team led by Japanese researchers said Thursday that it had created a miniature multiorgan structure from human induced pluripotent stem (iPS) cells, in a world first.
JAPAN
Jul 24, 2019
Japanese research into growth of human organs in animals gets preliminary approval
A science ministry committee of experts on Wednesday approved Japan's first research involving the injection of human induced pluripotent stem (iPS) cells into fertilized animal eggs with the aim of growing human organs.
Japan Times
JAPAN / Science & Health
Apr 24, 2019
Eye-opener: Japanese doctor's work with iPS cells puts macular degeneration on notice
Science has Dr. Masayo Takahashi's mother to thank, in a way, for some of the most notable developments in regenerative medicine using stem cells.

Longform

Mount Fuji is considered one of Japan's most iconic symbols and is a major draw for tourists. It's still a mountain, though, and potential hikers need to properly prepare for any climb.
What it takes to save lives on Mount Fuji