The virus is winning. That much is certain more than six months into a shape-shifting pandemic that’s killed 450,000 people worldwide, is gaining ground globally and has disrupted lives from Wuhan to Sao Paulo.

While promising, fast-moving vaccine projects are underway in China, Europe and the U.S., only the most optimistic expect an effective shot to be ready for global distribution this year.

If, as most experts believe, an effective vaccine won’t be ready until well into 2021, we’ll all be coexisting with the coronavirus for the next year or longer without a magic bullet. And this next phase of the crisis may require us to reset our expectations and awareness and change our behavior, according to public-health professionals.