China’s largest documented outbreak continues to spread despite an extended lockdown of Shanghai’s 25 million people, weighing on a fragile economy and straining global supply chains.

There were 26,087 new daily infections reported in the Chinese financial hub on Sunday, an all-time high. Residents have been locked down for weeks now, with frustration building among the population as they struggle to get access to food and medical care.

Elsewhere, the southern metropolis of Guangzhou is implementing a series of restrictions after local authorities warned the 20 cases they found in the latter part of last week could be the tip of the iceberg.