A growing body of preliminary research suggests the COVID vaccines used in most of the world offer almost no defense against becoming infected by the highly contagious omicron variant.

All vaccines still seem to provide a significant degree of protection against serious illness from omicron, which is the most crucial goal. But only the Pfizer and Moderna shots, when reinforced by a booster, appear to have initial success at stopping infections, and these vaccines are unavailable in most of the world.

The other shots — including those from AstraZeneca, Johnson & Johnson and vaccines manufactured in China and Russia — do little to nothing to stop the spread of omicron, early research shows. And because most countries have built their inoculation programs around these vaccines, the gap could have a profound impact on the course of the pandemic.