Biogen Inc. took a colossal risk in late 2019. It revived a drug for Alzheimer’s disease it had left for dead earlier that year after the medication appeared to fail two large clinical trials.

The company wasn’t ready to take no for an answer. Biogen, along with its Tokyo-based partner Eisai Co. Ltd., had poured years of effort into developing the therapy, then called aducanumab, and was counting on it as its next big therapeutic advance.

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