Bill and Melinda Gates, who for decades have overseen one of history’s greatest fortunes and philanthropic operations, have said they plan to divorce.

The announcement Monday that the couple is splitting after 27 years of marriage has the power to ripple through the technology industry, a vast portfolio of business and real estate holdings and into the realms of global health, climate change policy and social issues including equality for women.

The pair, who command an estimated $146 billion, according to the Bloomberg Billionaires Index, made no public hint of their financial plans, though they emphasized that they will cooperate on continuing their philanthropy.