Nearly a third of hospitalized COVID-19 patients experienced some type of altered mental function — ranging from confusion to delirium to unresponsiveness — in the largest study to date of neurological symptoms among coronavirus patients in a U.S. hospital system.

And patients with altered mental function had significantly worse medical outcomes, according to the study, published Monday in Annals of Clinical and Translational Neurology. The study looked at the records of the first 509 coronavirus patients hospitalized, from March 5 to April 6, at 10 hospitals in the Northwestern Medicine health system in the Chicago area.

These patients stayed three times as long in the hospital as patients without altered mental function.