CHICAGO – Tests of lung samples taken from 29 patients with vaping-related injuries suggest all contained vitamin E acetate, a discovery U.S. officials described on Friday as a “breakthrough” in the investigation of the nationwide outbreak that has topped 2,000 cases.
The discovery of vitamin E acetate in lung samples offers the first direct evidence of a link with the substance and vaping-related lung injuries. The substance has also been identified in tests by U.S. and state officials of product samples collected from patients with the vaping injury.
In a telephone briefing on Friday, Dr. Anne Schuchat, principal deputy director of the U.S. Centers for Disease Control and Prevention (CDC), called vitamin E acetate “a very strong culprit of concern” and referred to the discovery as “a breakthrough” in the investigation.
She cautioned that more work is needed to definitively declare it a cause, and said studies may identify other potential causes of the serious injuries as well.
Vitamin E acetate is believed to be used as a cutting agent in illicit vaping products containing THC — the component of marijuana that gets people high.
The substance was identified early in product testing done in the New York Health Department’s Wadsworth laboratory, but not every THC vaping pen the lab tested contained vitamin E, a lab official told Reuters.
Schuchat said researchers must now establish a causal link between exposure and injury, adding that “many substances are still under investigation.”
On Thursday, the CDC reported there have been 2,051 confirmed and probable U.S. lung injury cases and 39 deaths associated with use of e-cigarettes, or vaping products. Nearly 85 percent of lung injury patients in the nationwide outbreak have reported using products containing THC.
In the CDC analysis, THC was detected in 23 of 28 patient samples of lung cells, including from three patients who said they did not use THC products. Nicotine was detected in 16 of 26 patient samples.
In a separate report, Illinois officials found that compared to vapers who did not get sick, those who had a lung injury were significantly more likely to use THC-containing vaping products exclusively or frequently, and were nine times more likely to have purchased products from illicit sources, such as from on-line or off the street.
Together, the findings reinforce public health officials’ recommendation that people avoid using e-cigarettes that contain THC or any products that come from illicit sources.