Democratic presidential front-runner Hillary Clinton's campaign signaled on Wednesday plans for a big assault on Republican Donald Trump even as she battles to hold off rival Bernie Sanders in California.

Clinton, a former secretary of state, is to deliver what her campaign described as a major speech on Thursday in San Diego to underscore what she feels would be the threat posed by Trump to U.S. national security if he is elected president on Nov. 8.

The effort to define Trump as unfit to be commander-in-chief comes as Clinton faces fierce opposition from Sanders, a U.S. senator from Vermont who has insisted on staying in the fight for the Democratic presidential nomination despite Clinton's nearly insurmountable lead.