A team of scientists has found "robust evidence" that the condition called chronic fatigue syndrome (CFS) is a biological disorder, not psychological, but some experts questioned the findings.

The team, from Columbia University in the United States, identified in their research distinct immune changes in patients with CFS — markers that they said pointed to distinct disease stages and would lead to better diagnosis and treatment.

CFS, sometimes called myalgic encephalomyelitis (ME), is a controversial and debilitating condition characterized by disabling physical and mental fatigue, poor concentration and memory, disturbed sleep and muscle and joint pain.