It's not a particularly strategic location, the United States and its allies never pledged to defend it, and few people outside the region had even heard of it before this month.

But the symbolism of U.S.-led airstrikes failing to stop Islamic State militants from overrunning the Syrian city of Kobani could provide an early setback to U.S. President Barack Obama's three-week old Syria air campaign — far beyond its battlefield importance.

If Islamic State seizes full control of the city — which U.S. officials acknowledge is possible in coming days — it would be able to boast that it has withstood American air power. A U.S.-led coalition has launched 50 strikes against militant positions around the city, most of those in the past four days.