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On which problems should we focus research in medicine and the biological sciences? There is a strong argument for tackling the diseases that kill the most people — diseases like malaria, measles and diarrhea, which kill millions in developing countries, but very few in the developed world.

Developed countries, however, devote most of their research funds to the diseases from which their citizens suffer, and that seems likely to continue for the foreseeable future. Given that constraint, which medical breakthrough would do the most to improve our lives?

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