Joe Biden, now the presumptive Democratic presidential nominee, is in the earliest stages of choosing a running mate who can help him defeat President Donald Trump in November, a decision complicated by the effects of the coronavirus crisis on the country and the campaign.

Biden, who is far behind Trump in fund-raising and hamstrung by social distancing rules, is preparing to begin his vetting process in the coming days, according to a person familiar with the plans. Yet alongside the usual political considerations, he will have to add a new factor: Who can best address the challenges of the COVID-19 era?

High profile senators — and former presidential candidates — Kamala Harris, Amy Klobuchar and Elizabeth Warren are all sure to get consideration. Yet the crisis has also raised the profile of Michigan Gov. Gretchen Whitmer, who Biden has said he was watching closely even before the pandemic struck.