The Buffalo Bills will begin their quest for a long-awaited Super Bowl title when they face the reigning champion Los Angeles Rams on Thursday in the first game of an NFL season that could be the last for decorated Tampa Bay Buccaneers quarterback Tom Brady.

Buffalo, which famously lost four consecutive Super Bowls in the early 1990s, has an elite quarterback, Josh Allen, at the helm of a dynamic offense that can strike fear into defenses and has been tabbed as the early favorite to win it all.

"It'll be a big challenge for us," Bills coach Sean McDermott said of opening the year against the Rams. "They're the defending Super Bowl champs, (and) at their place, so we've got to play good team ball."