The first omicron cases in the U.S. were detected mostly in vaccinated people who experienced mild illnesses, with only one hospitalization and no deaths reported so far, the U.S. Centers for Disease Control and Prevention said.

As of Dec. 8, the U.S. had investigated 43 cases of the COVID-19 variant that set the world on high alert last month because of mutations that may make it spread more easily.

About four-fifths of those cases occurred in people who had been fully vaccinated, the CDC said on Friday, including one who was in the hospital for two days. Common symptoms included cough, tiredness and congestion or runny nose, according to the agency’s Morbidity and Mortality Weekly Report.