A quiet revolution has permeated global health circles. Authorities have come to accept what many researchers have argued for over a year: The coronavirus can spread through the air.

That new acceptance, by the World Health Organization and the U.S. Centers for Disease Control and Prevention, comes with concrete implications: Scientists are calling for ventilation systems to be overhauled like public water supplies were in the 1800s after fetid pipes were found to harbor cholera.

Cleaner indoor air won’t just fight the pandemic, it will minimize the risk of catching the flu and other respiratory infections that cost the U.S. more than $50 billion a year, researchers said in a study in the journal Science on Friday. Avoiding these germs and their associated sickness and productivity losses would, therefore, offset the cost of upgrading ventilation and filtration in buildings.