The U.S. Environmental Protection Agency has said that glyphosate, the key ingredient in Monsanto Co.'s top-selling weed killer Roundup, is not likely to be carcinogenic to humans, contradicting a World Health Organization panel.

The EPA, in a draft risk assessment report issued on Monday, also said it found "no other meaningful risks to human health" when glyphosate, the world's biggest-selling weed killer, is used according to its label instructions.

For more than 40 years, farmers have applied glyphosate to crops, most recently as they have cultivated genetically modified corn and soybeans. Roundup is also sprayed on residential lawns and golf courses.