OSAKA — The nuclear energy cooperation agreement signed Tuesday by Japan and Russia is expected to be a great boon to firms like Toshiba that are seeking new international markets for their atomic power technology, as well as ensuring Japan a steady supply of enriched uranium for its own electricity plants.

But the deal also raises international concerns about environmental issues related to the mining of uranium, and worldwide questions about the further spread of nuclear technology and transport safety of re-enriched uranium to Japan.

Tuesday's agreement marked the end of a two-year negotiating process between Tokyo and Moscow to cooperate on peaceful uses of nuclear energy.