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Let's discuss iPS cells

This week’s featured article

KYODO

The University of Tokyo plans to start an experiment to grow human pancreases in pigs for transplantation using induced pluripotent stem cells, better known as iPS cells, a professor leading the project said recently.

Professor Hiromitsu Nakauchi said he hopes to launch the first project in the country to grow human organs in animals within a year or so, once it clears government and university screening committees, and use genetically engineered pancreases in the treatment of disorders such as serious diabetes within 10 years.

The decision by Nakauchi’s research team comes after the Japanese government lifted a ban on producing animals with embryos containing human cells, as the supply of donated organs continues to lag behind demand from patients awaiting transplants.

Nakauchi’s team will inject human iPS cells, which can grow into any kind of cells, into a pig embryo genetically modified so that it lacks the ability to develop a pancreas. The embryo will then be placed in a surrogate sow’s uterus.

The fetus will be removed before delivery to examine the amount of pancreas tissue derived from the human iPS cells and how well it functions.

The Japanese government still prohibits the placement of fertilized animal eggs containing human cells in human wombs as well as the use of animals produced through such genetic engineering for breeding. Such experiments using pigs have already been conducted overseas.

Published in The Japan Times on April 28.

Warm up

Have a one-minute chat about health.

Game

Collect words related to health, e.g.: doctor, medicine, surgery

New words

1) embryo: an unborn or unhatched offspring in the early stages of growth, e.g., “An embryo is vulnerable to viruses, so mothers must stay healthy.”

2) surrogate: a substitute, e.g., “Politicians use surrogates to make speeches for them when they can’t attend a rally.”

3) uterus: an organ in female mammals that usually nourishes an unborn child, e.g., “She got cancer in her uterus and will have to undergo an operation.”

Guess the headline

University of Tokyo plans experiment to grow human o_ _ _ _ s in p_ _ s within about a year

Questions

1) What is the purpose of the experiment?

2) Is the experiment the first one of its kind in the world?

3) What caused Hiromitsu Nakauchi’s research to move forward?

Let’s discuss the article

1) What do you think about this experiment?

2) What do you think has been the biggest achievement in medicine?

3) What medical achievement would you like to see in the future?

Reference

ひと昔前では治らないと言われていた病気の治療法が整えられていく中、体の一部を人工的に作り出すということさえも可能になってきました。これによって、治療が不可能な状態になってしまった体の一部を人工のものに置き換えることで体全体の健康を保つという、以前であれば空想のようなことが実現できることになります。ますます発展する医療テクノロジーに私たちはなにを望むでしょうか。また、その在り方はどうあるべきなのでしょうか。朝の会に参加し皆さんで話し合ってみましょう。

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