Shohei Ohtani hit his 33rd home run of the season as the Los Angeles Angels lost 5-4 to the Detroit Tigers on Wednesday.

With the game tied at 3-3 in the seventh, Ohtani ripped a 2-0 sinker from the Tigers' fourth pitcher Andrew Chafin over the center-field wall for a solo home run at Angel Stadium.

Batting third as the designated hitter, Ohtani's sixth homer in nine games was his only hit. For the second time this season, he struck out four times, to finish 1-for-5.

The Angels gave up two runs in the ninth on Kerry Carpenter's and Ryan Kreidler's solo homers off the Angels' Jose Quijada (0-4).

Yu Darvish earned his 13th win, meanwhile, after surrendering three runs all on solo shots over six-plus innings in the San Diego Padres' 6-3 win over the Arizona Diamondbacks.

Darvish (13-7) allowed both Daulton Varsho and Corbin Carroll to go deep in the second before a two-run homer from Jurickson Profar and a Jake Cronenworth solo shot in the home half gave the Padres the lead.

Varsho homered off Darvish again in the fourth to tie it, but Wil Myers' solo shot, the last of six homers in the game, in the bottom of the fourth gave the Padres the lead for good.

"There weren't many pitches I was satisfied with," Darvish said. "But at this time of year, winning is the important thing, and I'm happy to have won when my condition wasn't good."

Darvish left with two on and no outs in the seventh, but former Hanshin Tigers closer Robert Suarez got San Diego out of that jam, and Nick Martinez, who won nine games last season for the Fukuoka SoftBank Hawks, worked a scoreless eighth for the Padres.