Roger Federer's bid for a hat-trick of Australian Open titles was crushed on Sunday as Greek wunderkind Stefanos Tsitsipas rose up to floor the Swiss master and become his nation's first Grand Slam quarter-finalist.

In a match pitting the oldest and youngest players left in the men's draw, the 20-year-old Tsitsipas overhauled Federer 6-7 (11), 7-6 (3), 7-5 and 7-6 (5) under the lights of Rod Laver Arena, sparking delirium among Greek fans out in force at Melbourne Park.

The 37-year-old Federer, 20 times a Grand Slam champion, will rue his chances, having failed to convert any of the 12 break points he took from Tsitsipas over the course of a riveting clash laden with sparkling shot-making.