The U.S. government has cut deals with Johnson & Johnson and Moderna Inc. and said it is in talks with at least two other companies to prepare them to produce massive quantities of coronavirus vaccines even before safe and effective ones become available.

There are currently no approved treatments or vaccines specifically for COVID-19, the respiratory disease that has killed more than 35,000 people and infected over 745,000 globally in just a few months.

No vaccine is expected to be ready for use until at least 2021, as they must still be widely tested in humans before being administered to hundreds of millions, if not billions, of people to prevent infection.