The world's last woolly mammoths, sequestered on an Arctic Ocean island outpost, suffered from serious genetic defects caused by generations of inbreeding that may have hampered traits such as sense of smell and male fertility in the doomed population.

Scientists said on Friday that the genome of one of the last mammoths from Wrangel Island off Siberia's coast showed that the population was riddled with deleterious mutations. They resurrected genes from this mammoth in the laboratory to find clues about the demise of this illustrious Ice Age species.

Most woolly mammoths went extinct roughly 10,000 years ago amid a warming climate and widespread human hunting. But isolated populations survived for thousands of years after that on St. Paul Island in the Bering Sea and Wrangel Island in the Arctic Ocean. The Wrangel Island population was the last, disappearing roughly 4,000 years ago.