Israeli forces killed at least 41 Palestinians along the Gaza border on Monday as angry protesters demonstrated at the frontier hours on the day the United States opened its embassy in Jerusalem, health officials said.

It was the highest Palestinian death toll in a single day since a series of protests dubbed the "Great March of Return" began at the border with Israel on March 30, and since the 2014 Gaza war.

The health officials said 900 Palestinians were wounded, about 450 of them by live bullets.