Nagoya University researchers have succeeded in regenerating parts of dogs’ jawbones by using stem cells collected from their puppies’ teeth, Nagoya University Professor Minoru Ueda said Friday.
The group has formed a primary tooth bank so it can use stem cells from the teeth to conduct regenerative medicine research and apply the technique to fractures and other treatments.
In the experiment, the group used two pairs of dogs, with each pair consisting of a 2-year-old animal and one of its 2-week-old puppies. The group then collected stem cells, which have the ability to grow into other various types of cells, from the dental pulp of the puppies’ primary teeth and differentiated them into bone cells by cultivating and multiplying them.
The group then mixed the differentiated cells with platelet-rich plasma, which was made by concentrating the parents’ blood, and embedded the substance into holes made in the dog’s alveolar bones at the bases of their teeth.
The holes were about 1 cm in diameter and 1 cm deep.
Four weeks later, new bone appeared in the holes where the substance was embedded.