Mutations linked to allergies, asthma


U.S. scientists said Wednesday they have found a genetic link to allergies as well as certain connective tissue disorders.

The findings in the journal Science Translational Medicine show that a single genetic pathway may open the door to conditions such as asthma, food allergies and eczema.

The culprit appears to be mutations that lead to abnormal signals from a protein called transforming growth factor-beta, or TGF-beta. When its signaling goes awry, it unleashes a “cascade of events that culminates in the development” of allergies, said lead author Pamela Frischmeyer-Guerrerio, an immunologist at Johns Hopkins Children’s Center.