Tsunan Sake Brewery Speaks at the Symposium “The Potential of Sake × Longevity”
Niigata, Japan — Tsunan Sake Brewery Co., Ltd. (Head Office: Tsunan Town, Nakauonuma District, Niigata Prefecture; CEO: Kengo Suzuki; hereinafter “Tsunan Sake Brewery”) participated as a guest speaker at the symposium “Sake × Longevity” held on August 8, 2025 (Friday) at TAKANAWA GATEWAY Link Scholars’ Hub (LiSH). The event was hosted by Regenesome Inc.
At the symposium, cutting-edge research and commercialization trends connecting fermentation and longevity were shared. Tsunan Sake Brewery introduced its initiatives on sake upcycling and collaborative research on sake-derived nanoparticles (SAKESOME). Guests also enjoyed a welcome drink featuring the Junmai Daiginjo “GO TERRACE.”
Scientific Background
Aging is closely associated with increased oxidative stress, cellular senescence, and loss of tissue homeostasis—all of which critically influence healthy life expectancy. Fermentation-derived components such as ergothioneine, agmatine, and α-EG, as well as sake-derived nanoparticles (SAKESOME), have shown potential roles in antioxidant defense, vascular relaxation, and intercellular communication.
This event highlighted Tsunan Sake Brewery’s efforts to merge traditional sake brewing with advanced biotechnology—such as valorizing sake lees through upcycling and exploring bioactive components—to uncover new possibilities for Japanese sake.
Note: This information relates to academic research exploration and does not claim pharmaceutical efficacy.
Insights from SSI Sake Academy Lecturer, Mr. Watanabe Inari
Market & Policy: Domestic sake consumption is maturing, while global demand is expanding. Low-alcohol products, functional properties, and upcycling of byproducts are attracting growing interest in the international market. UNESCO’s recognition of sake brewing as an Intangible Cultural Heritage is accelerating both tradition and innovation.
Brewing Science: Japanese sake is brewed from rice, rice koji, and water through parallel multiple fermentation. Systematic approaches to raw material regulations, sensory analysis, and quality optimization are becoming mainstream.
Upcycling: Practical cases such as craft sake brewed using byproducts from hops illustrate how food loss reduction and new sensory experiences can coexist.
Key Topics Presented by Tsunan Sake Brewery
Sake Upcycling Project: Transforming sake lees and brewing byproducts into food ingredients and materials, integrating Art × Science × Craft with local sustainability in mind. Research collaboration on SAKESOME nanoparticles aims to unite flavor, functionality, and innovation.
Product Experience: Guests enjoyed GO TERRACE as a terroir-driven sake. With a foundation in traditional brewing, Tsunan Sake Brewery is advancing toward Smart Brewing—combining sensory evaluation with data-driven optimization for market adaptability.
Symposium Details
Theme: The Potential of Sake × Longevity
Date: Friday, August 8, 2025, 18:00–19:00 (Doors open at 17:45)
Venue: LiSH Studio1, Takanawa Gateway City THE LINKPILLAR 1 NORTH 7F, Minato-ku, Tokyo (Directly connected to JR Takanawa Gateway Station)
Audience: Corporate representatives, researchers, media professionals
Program:
17:45–18:00 Doors Open
18:00–18:10 Welcome Drink & Greetings (“GO TERRACE”)
18:10–18:50 Presentations (Watanabe Inari, Regenesome, Tsunan Sake Brewery)
18:50–19:00 Q&A and Closing
About “GO TERRACE”
Named after the rice terraces where the sake rice is cultivated, “GO TERRACE” is brewed with premium Uonuma Koshihikari rice grown in Niigata’s Tsunan region—famous for its high-quality rice and abundant snowmelt water. The sake delivers the delicate sweetness of Koshihikari with a clean, smooth umami finish reminiscent of fresh spring water.
About Regenesome Inc.
Regenesome Inc. is developing novel solutions for aging control and regenerative medicine using nanoparticles such as exosomes. By analyzing exosomes from various cells and designing nanoparticles at the molecular level, Regenesome aims to understand their biological functions and develop next-generation medical technologies—including applications for space medicine—to extend healthy life expectancy and enable human expansion into space.
https://regenesome.com/
About Tsunan Sake Brewery
Tsunan Sake Brewery Co., Ltd. is located in Tsunan Town, Niigata Prefecture, one of Japan’s heaviest snowfall regions. Using pristine natural water sourced from 2,000-meter-class mountains and locally grown sake rice varieties such as Gohyakumangoku and Uonuma Koshihikari, the brewery blends coexistence with nature and innovative brewing technologies. Its brand concept is “Brew for Future—Brewing a Future of Coexistence.” In 2025, Tsunan Sake Brewery won the Governor of Niigata Award (1st Place) at the Echigo-style Sake Brewing Technology Championship.
https://tsunan-sake.com/
