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Trials of untested Ebola drugs begin in West Africa

Reuters

Medical charities say they have started trials of untested drug treatments on Ebola patients in Liberia and Guinea for the first time in an effort to control an epidemic that has killed more than 8,000 people in the region.

The World Health Organization gave its approval for the use of experimental drugs on West African Ebola patients in August, but it has taken months to organize trials and get limited supplies of the drugs to the affected countries.

Medecins Sans Frontieres said on Tuesday it began giving brincidofovir, developed by North Carolina-based Chimerix Inc., to consenting confirmed Ebola patients this month at the ELWA 3 center in Monrovia.

Dr. Jake Dunning from Oxford University, which is leading the trials, said the antiviral drug has been effective in laboratory tests against Ebola-infected cells.

“What we don’t know yet is if it will be effective against Ebola in humans. This is why we must do a trial,” he said.

In Guinea, where the hemorrhagic fever first emerged deep in the jungle more than a year ago, trials of an experimental Japanese drug have begun in two Ebola treatment centers — Gueckedou and Nzerekore.

The drug Avigan, or favipiravir — developed by Toyama Chemical, a subsidiary of Fujifilm — was created as a flu treatment. It was administered to a Cuban doctor in a Swiss hospital in December after he contracted the virus in Sierra Leone. He survived.

Johnson & Johnson announced the start of clinical tests with a third experimental vaccine earlier on Tuesday .

Volunteers from Britain and Switzerland have already been given trial Ebola vaccines intended to immunize them against the virus, while experimental treatments have sometimes been offered to Ebola-stricken health care workers.

Isabelle Defourny, with medical charity the Alliance for International Medical Action operating the Nzerekore center, said she hoped the treatment would help push death rates down from their current level around 60 percent.

“The high mortality rate is tragic for the populations and makes it even harder to contain the epidemic because the patients, in the absence of effective treatments, are understandably reticent about coming to centers,” she said.

Ebola, thought to have jumped to humans via an infected fruit bat last year, causes vomiting and diarrhoea as well as bleeding from the eyes and ears in the late stages.

The first results for brincidofovir are expected in February and for favipiravir in late March. It was not immediately clear when drug trials would begin in Sierra Leone, the country with the highest number of cases.