Gamba Osaka crashed out of the Asian Champions League in the first round on Tuesday after a 2-1 defeat at home to South Korea's Suwon Samsung Bluewings.
Gamba striker Takashi Usami missed a twice-taken penalty and Santos gave Suwon the lead early in the second half before the Brazilian striker converted from the spot to complete his brace in the 57th minute. Yasuyuki Konno replied with a late consolation for Gamba.
Gamba, the 2008 champions and semifinalists last season, have yet to win and have just two points at the bottom of Group G with one game left.