Arctic cold extended its grip over much of the United States on Friday, combining with snow, ice and howling winds from a deadly winter storm roaring out of the Midwest to disrupt energy supplies and thwart travel for millions of Americans ahead of the holiday weekend.

The extreme winter weather, which prompted city authorities across the country to open warming centers in libraries and police stations while scrambling to expand temporary shelter for the homeless, was blamed for at least five deaths on Friday.

A 50-vehicle pileup on the Ohio Turnpike in a blizzard near Toledo killed two motorists, injured numerous others and shut down both lanes of the highway, state police reported.