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AstraZeneca Plc and the University of Oxford’s COVID-19 vaccine won U.K. clearance, marking the first approval worldwide for a shot that’s faced questions but will be key to mass immunizations.

The vaccine will be prioritized for the country’s most vulnerable groups, with shots starting Monday, according to the government. It’s the second coronavirus injection to be cleared for emergency use in the U.K. after Pfizer Inc. and BioNTech SE’s in early December.

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