Tokyo stocks continued to fall Wednesday, with the Nikkei index sinking to a nearly five-week low, as investor sentiment was hurt by the escalating trade row between the United States and China, which has renewed concern about global growth.

The 225-issue Nikkei average tumbled 321.13 points, or 1.46 percent, from Tuesday to 21,602.59, its lowest close since April 2. The broader Topix index of all first section issues on the Tokyo Stock Exchange finished 27.51 points, or 1.72 percent, lower at 1,572.33.

Every industry category lost ground, led by precision instrument, air transportation, and glass and ceramic product issues.