Drug-resistant malaria parasites have spread to border regions of Southeast Asia, seriously threatening global efforts to control and eliminate the mosquito-borne disease, researchers said on Wednesday.

The scientists, who analyzed blood samples from 1,241 malaria patients in 10 countries across Asia and Africa, found resistance to the world's most effective anti-malarial drug, artemisinin, is now widespread in Southeast Asia.

However, the study found no signs yet of resistance in the three African sites it covered in Kenya, Nigeria and Democratic Republic of the Congo.