Psilocybin, the psychedelic compound in magic mushrooms, may one day be an effective treatment for patients with severe depression who fail to recover using other therapies, scientists said on Tuesday.

A small-scale pilot study of psilocybin's use in cases of treatment-resistant depression showed it was safe and effective, the British researchers said.

Of 12 patients given the drug, all showed some decrease in symptoms of depression for at least three weeks. Seven continued to show a positive response at three months. Five remained in remission beyond the three months.