Two women with ovarian problems have produced fertile eggs through in vitro fertilization using sperm from their husbands and eggs donated from anonymous females, a nonprofit organization supporting fertility treatment said Monday.

While there have been 24 cases in Japan in which women have given birth by using sperm from their husbands and eggs from their sisters or friends, it is the first time that complete strangers had donated the eggs.

The development could bring attention to a host of issues Japan needs to deal with over egg donation, including ensuring the rights of children to know about their origins and compensation for health problems that donors could face when offering eggs.