The U.S. Senate vote Thursday to lower the barriers for presidential nominations will make it easier for President Barack Obama to accomplish key second-term priorities, including tougher measures on climate change and financial regulation, that have faced intense opposition from Republicans in Congress.

The move to allow a simple majority vote on most executive and judicial nominees also sets the stage for Obama to appoint new top officials to the Federal Reserve and other key agencies — likely leading to more aggressive action to stimulate the economy and housing market. And it frees Obama to make changes to his Cabinet without the threat of long delays in the Senate before the confirmation of nominees.

The most immediate effect will be felt at the U.S. Court of Appeals for the District of Columbia Circuit. Widely regarded as second only to the Supreme Court in influence, it plays a central role in upholding or knocking down federal regulations. The panel is evenly divided between Republicans and Democrats but has three vacancies that Obama has been attempting to fill.