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Study says modern-day dogs closely related to European canines

The Washington Post

Amid the harsh, icy lands of ancient Europe, early man found himself an unexpected companion — the snarling, carnivorous wolf — which would eventually become his modern-day counterpart’s best furry friend.

New genetic analysis of 148 prehistoric and modern animals has revealed that our present-day pooches, from dingoes to Saint Bernards, are most closely related to either ancient or modern European canines. The comprehensive study points to places like Germany and Switzerland as to where domestication of dogs likely began, and to free-roaming wolves evolving into the Rovers and Spots we know and love today.

The study was published online Thursday in the journal Science.

“The first dogs looked like wolves,” said study author and evolutionary biologist Robert K. Wayne of the University of California, Los Angeles. “It took some time before these proto-dogs started to look different.”

Wayne and his colleagues estimate domestication occurred around 18,800 to 32,100 years ago, when ice sheets extended over much of Europe’s northern lands. Hunter-gatherers feasted on huge kills, such as mammoths. But at the same time, early men looked over their shoulders for predatory cave bears and lions.

So when a few of the friendlier wolves started to hang around for leftover mammoth, perhaps the humans didn’t mind because they provided a little extra protection. They began the first step toward domestication by coexisting with wolves in a mutually beneficial relationship, the scientists speculate.

The docile wolves bred and stuck with their new human friends. They stopped intermingling as much with the wild wolves. After generations upon generations of selective breeding, wolves slowly became more like the dogs of today — still the only large carnivore ever domesticated, said Wayne. They even adapted to a high-starch diet, leaving them in better shape during human society’s later forays into agriculture.

Although there was no question that modern dogs descended from wolves, recent research findings clashed over where and when domestication originated.

Archeologists dug up the oldest doglike fossils dating back 36,000 years ago in Western Europe and Siberia, but it wasn’t certain if they truly were the bones of early dogs or some other creature. Curiously, the latest genetic studies traced back the family tree of modern dogs and wolves to canine origins in the Middle East or East Asia — tens of thousands of years after those first fossils.

“The fossils spoke for Europe, but the genetics spoke for Asia,” said study author and population geneticist at Finland’s University of Turku Olaf Thalmann. “At some point, you have to combine the two stories.”

So that’s exactly what Thalmann and his colleagues set out to do. The team gathered genetic data from 18 prehistoric doglike fossils from Eurasia and the New World, along with a slew from present-day dogs and wolves.

They nabbed insight on how to best work with old, battered DNA from the groundbreaking sequencing of the Neanderthal genome in 2010.

“Ancient DNA is shattered into many, many small pieces,” said National Institutes of Health geneticist Elaine Ostrander, who was not involved in the study. “When you have an ancient sample, sequencing the mitochondrial DNA is the right first thing to do.”

Mitochondria are miniorgans inside cells that also contain a bit of DNA, like the nucleus. But the DNA in the nucleus only has two copies, compared to up to a thousand copies of mitochondrial DNA in a single cell. When it comes to extracting prehistoric DNA, the more backup copies, the better.

In total, the team input 148 complete and partial mitochondrial sequences into a model that spit out an evolutionary tree. To the researchers’ surprise, all four of the living groupings of modern dogs had their closest ancestors in Europe, not Asia.

One group including a Siberian husky and a Great Dane had sequences most closely related to that of an ancient wolf from Switzerland. Ancestors for a second set of present-day dogs containing a pit bull terrier and a cocker spaniel included two ancient dogs found in Germany.

Also, two of the oldest fossils, including one from Siberia, were from creatures not directly related to today’s pooches. Thalmann thinks these may have been unsuccessful domestication efforts, where these wolves became partly doglike, but the branch of evolution got cut short somehow.

“There is not a single proto-dog — Eve, or Spot, they would call that dog — from which modern dog breeds descended,” said Ostrander. Today more than 300 breeds exist with humans continuing to select for fancier or odder traits. The majority of these are only a few hundred years old.

Ostrander, who has done research on dog genetics for more than 20 years, finds the results plausible given human trade routes and population migrations.

“Using state-of-the-art genome technologies, they have come up with very clear answers about what is likely to be the location of major dog domestication events,” she said. “All the pieces fit together very nicely.”