The wives of two HIV-positive men have been impregnated through in vitro fertilization after their husbands' semen was cleared of the virus, doctors at a Niigata university said Wednesday.

The first birth is expected this fall. Niigata University Faculty of Medicine carried out the procedures, the first of their kind performed in Japan.

Several blood tests on the women show they are free from HIV infection, and one of them is expected to give birth in the fall and the other next spring, the doctors said.

The university has notified the Ministry of Health, Labor and Welfare, and the Ministry of Education, Culture, Sports, Science and Technology about the case.